There are a few options that are available on the right hand side of the screen during game play. Simply select the "Guides" option, then choose "Suggestions". A box with a list of all the possible words you can play with your letters from highest to lowest will appear. To play the word, simply double click on the word of your choice on the list and it will be displayed on the game board. Then, click "Play". You will win almost all of the time under any difficulty setting against any number of players (including CPU opponents).